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Showing posts from March 28, 2021

Show HN: A peptide design tool for cancer vaccine https://ift.tt/39BVLFl

Show HN: A peptide design tool for cancer vaccine Dear HNers, I have coded a tool that hopefully could help oncologists to design a peptide vaccine for personalized medicine. https://ift.tt/3dxXnkF Some peptides are specific to cancers. A peptide vaccine is a way to train our body to eradicate the cells that harbor these peptides on their outer membrane. Peptide vaccines are notoriously ineffective but safe, so they could be a second line of defense against cancer after traditional drugs and therapies. A tumor develops many mutations, over time. So there is no standard medical answer. A peptide vaccine will therefore be composed of a set of peptides, which may vary over time. Because peptide vaccines can be designed very quickly, they can help respond as soon as drug resistance develops. Peptide vaccines could be a way for oncologists to distinguish themselves from their colleagues in practice, and allow them to express their know-how. This service uses its own MHC prediction service i
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Show HN: Bugout.dev – Crash and usage reports for developer tools https://ift.tt/3dCTWtl

Show HN: Bugout.dev – Crash and usage reports for developer tools Hello everyone, I’m Sophia, founder of Bugout.dev. I started off as a professional ballerina, and entered technology later in my working life - through the OpenAI Scholars program. My co-founder, Neeraj (zomglings on HN), is a mathematician and now programmer. When I was learning how to code I kept running into issues. I found Stackoverflow and GitHub issues hard to navigate, often leading me to outdated solutions to the problems I was experiencing. That experience made me want a product that would collect crashes and immediately let the creators of the software I was using know about the issue. And when they or their community had fixed the issue, they could notify me about that and direct me to a public site detailing the solution. Over time, this idea evolved and resulted in Bugout.dev. Bugout makes it easy for creators of developer tools to collect usage metrics and crash reports from their users. This applies equall
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Muni’s Equity Toolkit Helps Essential Employees Get to Work

Muni’s Equity Toolkit Helps Essential Employees Get to Work By Mariana Maguire The latest data from SFMTA’s new  Equity Toolkit  shows that Muni service changes are helping people in neighborhoods identified by our  Muni Service Equity Strategy  access more jobs and support the city’s recovery.   In winter 2020, we launched the  SFMTA Equity Toolkit  to understand how service decisions are affecting neighborhoods where there is likely a high prevalence of essential workers who rely predominantly on Muni to get to their essential jobs. Our goal is to make better service decisions based on the trends and impacts we see in the Equity Toolkit.   Recently, the greatest increases in access to jobs via Muni have been in Hunters Point and Western Addition. The Hunters Point neighborhood saw the largest gains from the addition of the  15 Bayview-Hunters Point Express , as demonstrated in the table below. Thanks to the return of key Muni lines and increased frequencies on connector routes, I
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SFMTA’s Cable Car Signal Tower Gets a Refresh

SFMTA’s Cable Car Signal Tower Gets a Refresh By Jeremy Menzies At the corner of California and Powell Streets stands a diminutive but important building that has been in use for well over 100 years. This octagonal signal tower controls the crossing of the Powell and California Street cable car lines, and recently underwent a full restoration thanks to the skilled craftspeople at the Cable Car Division. A group photo of Muni craftspeople and shop management who worked to restore the signal tower in 2020-2021. The tower’s history dates to 1888 when the original was built by the Ferries and Cliff House Railroad, which operated cable cars on Powell Street at the time. That tower was destroyed in the 1906 earthquake and fires that ravaged Nob Hill. In March 1907, it was rebuilt by then-owner United Railroads of San Francisco (URR) and went back into operation. Photo showing signal tower in 1908 with the Fairmont Hotel and passengers waiting for a cable car in the background. Photo c
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