Show HN: A peptide design tool for cancer vaccine Dear HNers, I have coded a tool that hopefully could help oncologists to design a peptide vaccine for personalized medicine. https://ift.tt/3dxXnkF Some peptides are specific to cancers. A peptide vaccine is a way to train our body to eradicate the cells that harbor these peptides on their outer membrane. Peptide vaccines are notoriously ineffective but safe, so they could be a second line of defense against cancer after traditional drugs and therapies. A tumor develops many mutations, over time. So there is no standard medical answer. A peptide vaccine will therefore be composed of a set of peptides, which may vary over time. Because peptide vaccines can be designed very quickly, they can help respond as soon as drug resistance develops. Peptide vaccines could be a way for oncologists to distinguish themselves from their colleagues in practice, and allow them to express their know-how. This service uses its own MHC prediction service in PHP (derived from PSSMHCpan). So it is faster than NetMHCPan, but alas, it is currently hosted on a cheap VPS so it cannot take much load. I wonder if you could suggest some business model for this kind of tool? Thanks! April 4, 2021 at 03:13AM
Women Pioneers at Muni: Adeline Svendsen and Muni’s First Newsletter By Jeremy Menzies To close out Women’s History Month, here’s a look back at one woman whose work to bring Muni staff together in the late 1940s created a legacy that lives on to this day. Adeline “Addy” Svendsen was founding editor of Muni’s first internal newsletter, “ Trolley Topics .” Adeline Svendsen sits at her desk in the Geneva Carhouse office building in this 1949 shot. Trolley Topics was a new venture when it started in February 1946. As Svendsen wrote in the first issue it was created, “to bring a little fun, a little news, and a lot of good will to all our fellow employees in the Railway.” Just two years prior in 1944, Muni merged with the Market Street Railway Company, expanding the small municipal operation into the largest transit provider in the city with hundreds of employees, vehicles of every shape and size, and dozens of facilities scattered across town. The newsletter was meant to help unite ...
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